4CE is an international consortium for electronic health record (EHR) data-driven studies of the COVID-19 pandemic. The goal of this effort—led by the i2b2 international academics users group—is to inform doctors, epidemiologists and the public about COVID-19 patients with data acquired through the health care process.

Phase 1 Results

Results from the first phase of data acquisition and analysis have been published to npj Digital Medicine, "International Electronic Health Record-Derived COVID-19 Clinical Course Profile: The 4CE Consortium."

Phase 1.1 Main Results

Results from Phase 1.1 of data acquisition and analysis have been submitted to medRxiv as a preprint, "International Comparisons of Harmonized Laboratory Value Trajectories to Predict Severe COVID-19: Leveraging the 4CE Collaborative Across 342 Hospitals and 6 Countries: A Retrospective Cohort Study."

Phase 1.1 Severity Definition Results

Results from the severity definition process during Phase 1.1 have been submitted to medRxiv as a preprint, "Validation of a Derived International Patient Severity Phenotype to Support COVID-19 Analytics from Electronic Health Record Data."

Phase 1.1 Neurological Phenotype Analysis Results

Results from neurological phenotype analysis during Phase 1.1 have been submitted to medRxiv as a preprint, "Multinational Prevalence of Neurological Phenotypes in Patients Hospitalized with COVID-19."

Considerations on Utilizing EHR Data

A viewpoint article on considerations that are crucial for appraising studies utilizing EHR data has been submitted to JMIR, "What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask."

Joining the Consortium

If you are interested in joining the 4CE project, please visit the join page.